Creatinine Clearance

Calculate creatinine clearance from a timed urine collection (time, volume, and creatinine concentration), and plasma creatinine. In pediatrics, it is generally corrected to a body surface area of 1.73 m2 (standard body surface area of an adult).

The formula for the calculation is as below. The BSA here is calculated from the height and weight with the formula of DuBois and DuBois.

CrCl =	UCr * UVol
	PCr * Tmin

Corrected CrCl = CrCl *	1.73
	BSA

Reference range in our laboratory of an "uncorrected" creatinine clearance for an adult male is 90-139 mL/minute, and for an adult female is 80-125 mL/minute. Many medications must be adjusted for renal impairment when the CrCl falls below 50 mL/min.